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Association of vitamin D supplementation with respiratory tract infection in infants.
- Source :
-
Maternal & Child Nutrition . Jul2020, Vol. 16 Issue 3, p1-10. 10p. - Publication Year :
- 2020
-
Abstract
- Vitamin D deficiency has been reported to be associated with respiratory tract infection (RTI). However, evidence regarding the effects of vitamin D supplementation on susceptibility of infants to RTI is limited. In this prospective birth cohort study, we examined whether vitamin D supplementation reduced RTI risk in 2,244 infants completing the follow‐up from birth to 6 months of age. The outcome endpoint was the first episode of paediatrician‐diagnosed RTI or 6 months of age when no RTI event occurred. Infants receiving vitamin D supplements at a daily dose of 400–600 IU from birth to the outcome endpoint were defined as vitamin D supplementation and divided into four groups according to the average frequency of supplementation: 0, 1–2, 3–4, and 5–7 days/week. We evaluated the relationship between vitamin D supplementation and time to the first episode of RTI with Kaplan–Meier plots. The associations of vitamin D supplementation with infant RTI, lower RTI (LRTI), and RTI‐related hospitalization were assessed using modified Poisson regression. The median time to first RTI episode was 60 days after birth (95% CI [60, 90]) for infants without supplementation and longer than 6 months of age for infants with supplementation (p <.001). We observed inverse trends between supplementation frequency and risk of RTI, LRTI, and RTI‐related hospitalization (p for trend <.001), with the risk ratios in the 5–7 days/week supplementation group of 0.46 (95% CI [0.41, 0.50]), 0.17 (95% CI [0.13, 0.24]), and 0.18 (95% CI [0.12, 0.27]), respectively. These associations were significant and consistent in a subgroup analysis stratified by infant feeding. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTIC use of vitamin D
*ANALYSIS of variance
*CHI-squared test
*CONFIDENCE intervals
*DIETARY supplements
*PATIENT aftercare
*INTERVIEWING
*LONGITUDINAL method
*MOTHERS
*REGRESSION analysis
*RESEARCH funding
*RESPIRATORY infections
*T-test (Statistics)
*DATA analysis software
*DESCRIPTIVE statistics
*KAPLAN-Meier estimator
*LOG-rank test
*CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 17408695
- Volume :
- 16
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Maternal & Child Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 143797907
- Full Text :
- https://doi.org/10.1111/mcn.12987