A fluorescent Zn(II)-based coordination polymer for selective detection of Fe3+ ion and treatment effect and mechanism against B.burgdorfert induced vulvar lichen sclerosus.

A new Zn(II)-based coordination polymer (CP) [Me 2 NH 2 [Zn 3 (OH) (L) 2 (H 2 O) 3 ·6H 2 O (1) has been successfully prepared utilizing a ligand of 4,4′,4″-s-triazine-1,3,5-triyltri-m-aminobenzoate (H 3 L) with triazine backbone. Complex 1 could be applied as a Fe3+ sensor with high sensitivity and selectivity. Furthermore, the treatment activity of 1 against vulvar lichen sclerosus (VLS) was assessed and its particular mechanism was discussed in the study. Firstly, the titer of the Borrelia burgdorferi (B.burgdorfert) was measured. Then the flow cytometry was carried out to determine the relative content of the T cell subset in peripheral blood. The superoxide dismutase (SOD) and malondialdehyde (MDA) method was used to measure the level of the SOD activity and MDA. Reverse transcription-polymerase chain reaction (RT-PCR) was carried out for the determination of the inflammatory genes nf-κb and p53 relative expression. The apoptosis of the vulvar disease tissue was evaluated. • A new Zn(II)-based coordination polymer (CP) (1) has been successfully prepared. • Complex 1 could be applied as a Fe3+ sensor with high sensitivity and selectivity. • The treatment activity of 1 against vulvar lichen sclerosus (VLS) was assessed. [ABSTRACT FROM AUTHOR]