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Factors associated with negative conversion of viral RNA in patients hospitalized with COVID-19.
- Source :
-
Science of the Total Environment . Aug2020, Vol. 728, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- Factors associated with negative conversion of SARS-CoV-2 RNA in hospitalized patients have not yet been systematically determined. We conducted a retrospective cohort study of COVID-19 patients in Qingdao, China. Both univariate and multivariate analysis were performed to identify independent factors for time to viral RNA negative conversion. Data on patients with re-detectable viral RNA after showing negative on RT-PCR test (intermittent negative status) were also analyzed. A total of 59 patients confirmed with COVID-19 were included in this study, with a median duration of 1 (interquartile range, IQR: 0–2) day from symptom onset to hospital admission. Median communicable period (from first day of positive nucleic acid test to first day of consecutive negative results) was 14 (IQR: 10–18) days, and 7 (IQR: 6–10) days for 10 patients with intermittent negative results. Age older than 45 years (hazard ratio, HR: 0.378; 95% confidence interval, CI: 0.205–0.698) and chest tightness (HR: 0.290; 95%CI: 0.091–0.919) were factors independently affecting negative conversion of SARS-CoV-2 RNA. Headache (odds ratio: 7.553; 95%CI: 1.011–28.253) was significantly associated with intermittent negative status, with a predicted probability of 60%. Older age and chest tightness were independently associated with delayed clearance of SARS-CoV-2 RNA in hospitalized patients. These predictors would provide a new perspective on early identification of patients with prolonged viral shedding and facilitate optimal isolation protocols and treatment strategies. Unlabelled Image • Older age were independently associated with delayed clearance of SARS-CoV-2 RNA. • Chest tightness were independently associated with delayed clearance of SARS-CoV-2 RNA. • Intermittent negative status was predicted a probability of 60% if occurring headache. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00489697
- Volume :
- 728
- Database :
- Academic Search Index
- Journal :
- Science of the Total Environment
- Publication Type :
- Academic Journal
- Accession number :
- 143768432
- Full Text :
- https://doi.org/10.1016/j.scitotenv.2020.138812