Back to Search
Start Over
Stratification to predict the response to antioxidant treatment in critical care: a translational study.
- Source :
-
Revista Brasileira de Terapia Intensiva . Jan-Mar2020, Vol. 32 Issue 1, p108-114. 7p. - Publication Year :
- 2020
-
Abstract
- Objective: To examine the effectiveness of stratification to identify and target antioxidant therapy for animal models of lethal sepsis and in patients who develop sustained hypotension. Methods: Rats were subjected to sepsis induced by cecal ligation and puncture. Animals were divided into two groups: those with high and low plasma levels of interleukin-6. Following stratification, N-acetylcysteine plus deferoxamine or saline was administered to animals starting 3 and 12 hours after surgery. N-Acetylcysteine plus deferoxamine or placebo was administered within 12 hours of meeting the inclusion criteria in hypotensive patients. Results: N-Acetylcysteine plus deferoxamine increased survival in the cecal ligation and puncture model when administered 3 and 12 hours after sepsis induction. When dividing animals that received antioxidants using plasma interleukin-6 levels, the protective effect was observed only in those animals with high IL-6 levels. The antioxidant effect of N-acetylcysteine + deferoxamine was similar in the two groups, but a significant decrease in plasma interleukin-6 levels was observed in the high-interleukin- 6-level group. Compared with patients treated with antioxidants in the lowinterleukin- 6 subgroup, those in the high-interleukin-6 subgroup had a lower incidence of acute kidney injury but were not different in terms of acute kidney injury severity or intensive care unit mortality. Conclusion: Targeting antioxidant therapy to a high inflammatory phenotype would select a responsive population. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTIOXIDANTS
*CRITICAL care medicine
*INTERLEUKIN-6
Subjects
Details
- Language :
- English
- ISSN :
- 0103507X
- Volume :
- 32
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Revista Brasileira de Terapia Intensiva
- Publication Type :
- Academic Journal
- Accession number :
- 143751894
- Full Text :
- https://doi.org/10.5935/0103-507X.20200016