VapBC22 toxin-antitoxin system from Mycobacterium tuberculosis is required for pathogenesis and modulation of host immune response.

The article discusses need for VapBC22 toxin-antitoxin system from Mycobacterium tuberculosis for pathogenesis and modulation of host immune response. Topics include overexpression of VapC22 toxin in M. tuberculosis results of metabolic enzymes; association of reduced expression of virulence-associated proteins and increased levels of cognate antitoxin; and upregulation of transcripts involved in innate immune responses and tissue remodeling in mice infected with the mutant strain.