超前镇痛对 VATS 肺叶切除患者阿片类药物使用的影响.

Objective: To investigate the effect of preoperative acetaminophen and gabapentin on opioid consumption and nausea and vomiting in patients undergoing video-assisted thoracoscopic lobectomy. Method (s): Patients who underwent video-assisted thoracoscopic lobectomy for non-small cell lung cancer from January 2016 to December 2018 were enrolled. Clinical data were collected including age, gender, BMI, comorbidities, anesthesia classification of American Society of Anesthesiologists, Tumor grading, tumor location, surgery time, intraoperative and postoperative opioid consumption, postoperative antiemetic application, opioid consumption was converted to oral morphine equivalent. Patients were divided into two groups according to whether preoperative analgesic regimen with acetaminophen and gabapentin was used. The preoperative basic conditions and the use of opioids during and after surgery were compared between the two groups. The effects of acetaminophen and gabapentin preemptive analgesia regimen on the use of opioids were analyzed. Result (s): A total of 241 patients were included in the study. 78 patients underwent preoperative analgesic regimen with acetaminophen and gabapentin, and 163 patients did not take this analgesic regimen. The doses of opioids, number of vomiting in 24 hours after surgery, and postoperative antiemetic in patients with preemptive analgesia were lower than those without preemptive analgesia. There was no significant difference in postoperative NSAIDs usage and sedation between the two groups. Conclusion (s): Preoperative analgesic regimen with acetaminophen and gabapentin can reduce the dose of opioids during and after surgery for patients undergoing video-assisted thoracoscopic lobectomy, and reduce postoperative nausea and vomiting. [ABSTRACT FROM AUTHOR]