Back to Search
Start Over
Congruence of patient- and clinician-reported toxicity in women receiving chemotherapy for early breast cancer.
- Source :
-
Cancer (0008543X) . Jul2020, Vol. 126 Issue 13, p3084-3093. 10p. - Publication Year :
- 2020
-
Abstract
- <bold>Background: </bold>The National Cancer Institute's Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events, collected alongside the clinician-reported Common Terminology Criteria for Adverse Events, enables comparisons of patient and clinician reports on treatment toxicity.<bold>Methods: </bold>In a multisite study of women receiving chemotherapy for early-stage breast cancer, symptom reports were collected on the same day from patients and their clinicians for 17 symptoms; their data were not shared with each other. The proportions of moderate, severe, or very severe patient-reported symptom severity were compared with the proportions of clinician-rated grade 2, 3, or 4 toxicity. Patient-clinician agreement was assessed via κ statistics. Chi-square tests investigated whether patient characteristics were associated with patient-clinician agreement.<bold>Results: </bold>Among 267 women, the median age was 58 years (range, 24-83 years), and 26% were nonwhite. There was moderate scoring agreement (κ = 0.413-0.570) for 53% of symptoms, fair agreement for 41% (κ = 0.220-0.378), and slight agreement for 6% (κ = 0.188). For example, patient-reported and clinician-rated percentages were 22% and 8% for severe or very severe fatigue, 41% and 46% for moderate fatigue, 32% and 39% for mild fatigue, and 6% and 7% for none. Clinician severity scores were lower for nonwhite patients in comparison with white patients for peripheral neuropathy, nausea, arthralgia, and dyspnea.<bold>Conclusions: </bold>Although clinician reporting of symptoms is common practice in oncology, there is suboptimal agreement with the gold standard of patient self-reporting. These data provide further evidence supporting the integration of patient-reported outcomes into oncological clinical research and clinical practice to improve monitoring of symptoms as well as timely interventions for symptoms. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANCER chemotherapy
*GEOMETRIC congruences
*PERIPHERAL neuropathy
*CHI-squared test
*POSTOPERATIVE nausea & vomiting
*HOT flashes
*THERAPEUTIC use of antineoplastic agents
*RESEARCH
*RESEARCH methodology
*ANTINEOPLASTIC agents
*MEDICAL cooperation
*EVALUATION research
*TUMOR classification
*COMPARATIVE studies
*DRUG therapy
*DRUG side effects
*BREAST tumors
*ONCOLOGY
*DISEASE complications
PERIPHERAL neuropathy diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 0008543X
- Volume :
- 126
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Cancer (0008543X)
- Publication Type :
- Academic Journal
- Accession number :
- 143610482
- Full Text :
- https://doi.org/10.1002/cncr.32898