Back to Search
Start Over
The cardiac isovolumetric contraction time is an independent predictor of incident heart failure in the general population.
- Source :
-
International Journal of Cardiology . Aug2020, Vol. 312, p81-86. 6p. - Publication Year :
- 2020
-
Abstract
- Color Tissue Doppler imaging (TDI) M-mode through the mitral leaflet is a novel method to obtain the cardiac time intervals including the isovolumic contraction time (IVCT), isovolumic relaxation time (IVRT) and ejection time (ET). The myocardial performance index (MPI) is defined as [(IVCT+IVRT)/ET]. Our aim was to investigate if the cardiac time intervals can be used to predict heart failure (HF) in the general population. A total of 1915 participants (mean age 58 ± 16 years, 42% male) from the general population (The Copenhagen City Heart Study) underwent a health examination including TDI-echocardiography. The primary endpoint was incident HF. Participants with a history of HF were excluded (n = 23). During a median follow-up time of 16 years, 172 (9%) participants were diagnosed with incident HF. The risk of HF increased with 24% per 10 ms increase in IVCT (per 10 ms increase: HR 1.24; 95%CI (1.14–1.36), p < 0.001). The association remained significant after adjusting for age, sex, hypertension, diabetes, previous ischemic heart disease, diastolic blood pressure, heart rate, body mass index, eGFR, proBNP, LVEF <50%, s′, LAVI, and E/e′ (per 10 ms increase: HR 1.13; 95% CI (1.00–1.27), p = 0.045). A significant association was found between MPI and HF both in unadjusted and adjusted models (per 0.1 increase: HR 6.93; 95% CI (1.63–29.31), p = 0.009). No associations between the IVRT or ET and HF remained significant after multivariable adjustment. In the general population the IVCT provides novel and independent prognostic information on the long-term risk of incident HF. • Color TDI M-mode is a novel method to obtain cardiac time intervals including IVCT. • The IVCT is a novel and independent predictor of HF in the general population. • The association remained significant even after multivariable adjustment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01675273
- Volume :
- 312
- Database :
- Academic Search Index
- Journal :
- International Journal of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 143574444
- Full Text :
- https://doi.org/10.1016/j.ijcard.2020.03.046