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Social skills and autism spectrum disorder symptoms in children with neurofibromatosis type 1: evidence for clinical trial outcomes.
- Source :
-
Developmental Medicine & Child Neurology . Jul2020, Vol. 62 Issue 7, p813-819. 7p. - Publication Year :
- 2020
-
Abstract
- <bold>Aim: </bold>We examined key features of two outcome measures for social dysfunction and autism spectrum disorder traits, the Social Responsiveness Scale, Second Edition (SRS-2) and the Social Skills Improvement System - Rating Scales (SSIS-RS), in children with neurofibromatosis type 1 (NF1). The aim of the study was to provide objective evidence as to which behavioural endpoint should be used in clinical trials.<bold>Method: </bold>Cross-sectional behavioural and demographic data were pooled from four paediatric NF1 tertiary referral centres in Australia and the United States (N=122; 65 males, 57 females; mean age [SD] 9y 2mo [3y], range 3-15y).<bold>Results: </bold>Distributions of SRS-2 and SSIS-RS scores were unimodal and both yielded deficits, with a higher proportion of severely impaired scores on the SRS-2 (16.4%) compared to the SSIS-RS (8.2%). Pearson's product-moment correlations revealed that both questionnaires were highly related to each other (r=-0.72, p<0.001) and to measures of adaptive social functioning (both p<0.001). Both questionnaires were significantly related to attention-deficit/hyperactivity disorder symptoms, but only very weakly associated with intelligence.<bold>Interpretation: </bold>The SRS-2 and SSIS-RS capture social dysfunction associated with NF1, suggesting both may be suitable choices for assessing social outcomes in this population in a clinical trial. However, careful thought needs to be given to the nature of the intervention when selecting either as a primary endpoint.<bold>What This Paper Adds: </bold>The Social Responsiveness Scale, Second Edition yielded a large deficit relative to population norms. The Social Skills Improvement System - Rating Scales yielded a moderate deficit relative to population norms. Both scales were highly correlated, suggesting that they are measuring a unitary construct. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHILDREN with autism spectrum disorders
*SOCIAL skills
*NEUROFIBROMATOSIS 1
*PEARSON correlation (Statistics)
*CLINICAL trials
*RESEARCH
*SOCIAL participation
*CROSS-sectional method
*RESEARCH methodology
*EVALUATION research
*MEDICAL cooperation
*PSYCHOLOGICAL tests
*COMPARATIVE studies
*RESEARCH funding
*STANDARDS
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 00121622
- Volume :
- 62
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Developmental Medicine & Child Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 143549872
- Full Text :
- https://doi.org/10.1111/dmcn.14517