Back to Search
Start Over
Enantioselective Twofold C−H Annulation of Formamides and Alkynes without Built‐in Chelating Groups.
- Source :
-
Angewandte Chemie International Edition . 6/8/2020, Vol. 59 Issue 24, p9428-9432. 5p. - Publication Year :
- 2020
-
Abstract
- Twofold C−H annulation of readily available formamides and alkynes without built‐in chelating groups was achieved. Ni−Al bimetallic catalysis enabled by a bulky BINOL‐derived chiral secondary phosphine oxide (SPO) ligand proved to be critical for high reactivity and high selectivity. This reaction uses readily available formamides as starting materials and provides a concise synthetic pathway to a broad range of chiral ferrocenes in 40–98 % yield and 93–99 % ee. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANNULATION
*ALKYNES
*PHOSPHINE oxides
*FORMAMIDE
*FERROCENE
*CATALYSIS
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 59
- Issue :
- 24
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 143547347
- Full Text :
- https://doi.org/10.1002/anie.202001267