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N‐terminal peptide deletion influences immunological and structural features of Blo t 5.
- Source :
-
Allergy . Jun2020, Vol. 75 Issue 6, p1503-1507. 5p. 2 Black and White Photographs. - Publication Year :
- 2020
-
Abstract
- Keywords: allergens and epitopes; IgE; immunotherapy vaccines and mechanisms EN allergens and epitopes IgE immunotherapy vaccines and mechanisms 1503 1507 5 06/01/20 20200601 NES 200601 Studies demonstrated that among the identified I B tropicalis i allergens, Blo t 5 is a major allergen,[[1], [3]] which makes the protein a target for diagnosis and allergen-specific immunotherapy (AIT). Cross-inhibition results showed that rBlo t 5 SB short sb cannot always inhibit the rDer p 5-specific IgE, but rDer p 5 possesses a moderate inhibitory capacity on rBlo t 5 SB short sb -specific IgE binding (Figure S4F). Blomia tropicalis Blo t 5 and Blo t 21 recombinant allergens might confer higher specificity to serodiagnostic assays than whole mite extract. [Extracted from the article]
- Subjects :
- *IMMUNOGLOBULIN E
*AMINO acid residues
Subjects
Details
- Language :
- English
- ISSN :
- 01054538
- Volume :
- 75
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 143491328
- Full Text :
- https://doi.org/10.1111/all.14176