Synthesis of an allosteric modulator of ionotropic glutamate receptors.

Authors :: Lavrov, Mstislav I.
Stroganov, Oleg V.
Zamoyski, Vladimir L.
Grigoriev, Vladimir V.
Zapolskiy, Maxim E.
Sysolyatin, Sergey V.
Malykhin, Valeriy V.
Surmachev, Vladimir N.
Palyulin, Vladimir A.
Source :: Mendeleev Communications. Mar2020, Vol. 30 Issue 2, p156-158. 3p.
Publication Year :: 2020
Abstract: Synthesis of 6-[4-methoxy-3-(pyrrolidin-1-ylmethyl)benzyl]-1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione has been carried out and optimized. In vitro studies using electrophysiological patch clamp technique have revealed a negative effect of this compound on kainateinduced currents in Purkinje neurons in a wide range of concentrations from 10−11 to 10−6 m. [ABSTRACT FROM AUTHOR]