'Pathogenesis and management of fracture-related infection' – Author's reply.

To the editor Although fracture-related infection (FRI) after open fractures is a well-known clinical challenge for orthopaedic trauma surgeons, standardized, internationally accepted guidelines are still lacking for the kind and duration of systemic perioperative antibiotic prophylaxis (PAP) [1]. Indeed, Yusuf et al. [3] found that in patients with Gustilo-Anderson type III injuries 47% of strains were resistant to amoxicillin/clavulanic acid at initial surgery, and 88% of strains were resistant at revision surgery. Currently, it remains at the discretion of the treating physicians (multidisciplinary team approach) to modify the spectrum of systemic PAP in individual patients with Gustilo-Anderson type III fractures based on local epidemiology and host status. [Extracted from the article]