HeLa ve Beas-2B Hücre Hatlarına Karşı Benzimidazolyum Tuzlarının İn Vitro Sitotoksik Aktivite Çalışmaları.

Six different heterocyclic compounds containing 1H-benzo[d]imidazole nuclei (S1-S6) were prepared in two steps and their structures were characterized using different spectroscopic methods. The synthesized heterocyclic compounds were tested against human cervix adenocarcinoma (HeLa) and human healthy lung (Beas-2B) cell lines. Cisplatin as a positive control drug was tested against the cervix cell line under the same conditions. Compound S4 was found to exhibit high cytotoxic activity against HeLa cell line (IC50: 3.72 ± 0.14 μM). In the last step of the study, color images of the cells interacted with the drug candidates were taken using confocal microscope. [ABSTRACT FROM AUTHOR]