The Relationship between Serum HMGB1, TGF - β1 and CT Image Scores after Craniocerebral Injury.

To analyze the relationship between high mobility group protein B1 (HMGB1), transforming growth factor - β1 (TGF- β1) and CT image scores after craniocerebral injury. From February 2017 to December 2018, 93 patients with craniocerebral injury were randomly selected from our hospital. According to the different CT imagescores, the patients were divided into three groups: group 0-5 points (24 cases), group 6-10 points (47 cases), group 11¬15 points (22 cases). The serum levels of high mobility group protein B1 (HMGB1), transforming growth factor - β1 (TGF- β1), interleukin (IL-12), C-reactive protein (CRP), myelin basic protein (MBP), neuron-specific enolase (NSE) and protein S100B (S100B) were measured by ELISA. Glasgow score was used to evaluate the severity of craniocerebral injury. Pearson correlation test was used to analyze the relationship between HMGB1, TGF - β1, MMP-2, MMP-9, IL-12, CRP, Glasgow score, MBP, NSE, S100B and CT image scores. There was no statistical significance (P > 0.05) of the significant difference in the comparison of clinical basic data such as age, gender, body mass index, type of brain injury and the causes of brain injury between each group. With the increase of CT image scores, the levels of HMGB1, IL-12, CRP, MBP, NSE and S100B in serum of the patients increased significantly, the levels of TGF - β1 and Glasgow score in serum decreased significantly (P<0.05). The level of HMGB1, TGF - β1, IL-12, CRP, MBP, NSE, S100B was the lowest in group 0-5 points' serum, and Glasgow was the highest; the group 6-10 points take the second place; the level of HMGB1, TGF - β1, IL- 12, CRP, MBP, NSE, S100B was the highest in group 11-15 points' serum, and Glasgow was the lowest. According to Pearson correlation test analysis, the levels of HMGB1, IL-12, CRP, MBP, NSE and S100B in serum were positively correlated with CT image scores, while the levels of TGF - β1 and Glasgow score were negatively correlated with CT image scores (P < 0.05). The level of HMGB1, IL-12, CRP, MBP, NSE, S100B, TGF - β1 and Glasgow score in serum were significantly correlated with CT image scores. The level of HMGB1, IL-12, CRP, MBP, NSE and S100B in serum level were positively correlated with CT image scores, while serum TGF - β1 levels and Glasgow scores were negatively correlated with CT image scores. All of the above indexes can be used as important indexes for the diagnosis of craniocerebral injury. [ABSTRACT FROM AUTHOR]