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Glutathione Serum Levels and Rate of Multimorbidity Development in Older Adults.
- Source :
-
Journals of Gerontology Series A: Biological Sciences & Medical Sciences . Jun2020, Vol. 75 Issue 6, p1089-1094. 6p. 1 Diagram, 2 Charts, 2 Graphs. - Publication Year :
- 2020
-
Abstract
- We aimed to investigate the association between baseline levels of total serum glutathione (tGSH) and rate of chronic disease accumulation over time. The study population (n = 2,596) was derived from a population-based longitudinal study on ≥60-year-olds living in Stockholm. Participants were clinically assessed at baseline, 3- and 6-year follow-ups. Multimorbidity was measured as the number of chronic conditions from a previously built list of 60 diseases. Linear mixed models were applied to analyze the association between baseline tGSH levels and the rate of multimorbidity development over 6 years. We found that at baseline, participants with ≥4 diseases had lower tGSH levels than participants with no chronic conditions (3.3 vs 3.6 µmol/L; p < .001). At follow-up, baseline levels of tGSH were inversely associated with the rate of multimorbidity development (β * time: -0.044, p < .001) after adjusting for age, sex, education, levels of serum creatinine, C-reactive protein, albumin, body mass index, smoking, and time of dropout or death. In conclusion, serum levels of tGSH are inversely associated with multimorbidity development; the association exists above and beyond the link between tGSH and specific chronic conditions. Our findings support the hypothesis that tGSH is a biomarker of multisystem dysregulation that eventually leads to multimorbidity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OLDER people
*COMORBIDITY
*GLUTATHIONE
*BODY mass index
*ADULT development
Subjects
Details
- Language :
- English
- ISSN :
- 10795006
- Volume :
- 75
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Journals of Gerontology Series A: Biological Sciences & Medical Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 143420868
- Full Text :
- https://doi.org/10.1093/gerona/glz101