Sevelamer/sodium polystyrene sulfonate interaction: Small bowel necrosis: case report.

B Author Information b An event is serious (based on the ICH definition) when the patient outcome is: * death * life-threatening * hospitalisation * disability * congenital anomaly * other medically important event * Drug interaction A 66-year-old man developed small bowel necrosis following concomitant use of sevelamer for hyperphosphataemia and sodium polystyrene sulfonate for hyperkalaemia [ I routes not stated i ]. The bowel resection specimen revealed acute ischaemic enteritis featuring mucosal ulceration associated with crystals morphologically compatible with sevelamer and sodium polystyrene sulfonate, acute organising serositis, submucosal arterial and venous thrombosis. SMALL BOWEL NECROSIS ASSOCIATED WITH A SINGLE DOSE KAYEXALATE TREATMENT IN A PATIENT WITH CHRONIC SEVELAMER THERAPY. [Extracted from the article]