Assessment of 25-hydroxy vitamen d in patients on regular hemodialysis in ain shams university hospital.

Background: Vitamin D deficiency (<20 ng/mL) and insufficiency (20-29 ng/mL) are common among patients with chronic kidney disease (CKD) or undergoing dialysis. Low 25(OH)D has been associated with high bone turnover, secondary hyperparathyroidism (SHPT), decreased bone mineral density (BMD), renal anemia, erythropoietin hypo responsiveness and sleep disturbance in CKD and dialysis patients Methods: This cross sectional study was carried out on 100 End Stage Renal Disease patients on Maintenance Hemodialysis in the Hemodialysis unit of Ain Shams University hospital, Cairo - Egypt. Assessment of serum level of 25(OH) VIT D, and to identify if possible relation between vitamin D deficiency and other parameter like hemoglobin level, Parathyroid hormone, Calcium, Phosphorus, Iron profile, DM, HTN, medications. Results: Vitamin D deficiency is common in end stage renal disease patients on regular hemodialysis, in our study we found that 50% of patients have 25(OH) VIT D deficiency, 34% are insufficient and only 16% was sufficient. There was no significant correlation between the serum level of 25(OH) VIT D and hemoglobin level and iron profile also no significant relation between 25(OH) vitamin D and PTH, calcium, phosphorus. Conclusion: Vitamin D deficiency and other disorders in calcium and phosphorus homeostasis are common in patient with end stage kidney disease on regular hemodialysis. We did not notice any significant relation between the levels of calcium, phosphorus, parathyroid hormone, serum albumin and vitamin D level. No significant relation between vitamin D level and hemoglobin level, iron profile. The National Kidney Foundation guidelines state that optimal 25(OH) D levels should be greater than 30 ng/ml. [ABSTRACT FROM AUTHOR]