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Diagnostic stewardship of Clostridioides difficile polymerase chain reaction results from syndromic diarrhea panel and implications for patient outcomes.
- Source :
-
Diagnostic Microbiology & Infectious Disease . Jun2020, Vol. 97 Issue 2, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- A syndromic gastrointestinal pathogen panel (GIP) was implemented in May 2018. All positive (+) GIP and standard-of-care (SOC) C. difficile results were reviewed. A single-center audit of adult patients with GIP results was conducted May–December 2018. We reviewed GIP(+)/SOC(+/-) and GIP(-)/SOC(-) tests (control group) for clinical outcomes. We reviewed 269 GIP(+) patients. Of 119 GIP(+)/SOC(+) patients, 44 (37%) were positive by toxin A/B enzyme immunoassay, and 75 (63%) by PCR only. Thirty-day mortality and re-admission were not significantly different between groups. CDI rates within 6 months were not significantly different between GIP(+)/SOC(-) and controls (p-value = 0.39). Those with initial SOC(+) tests had more true CDI events within 6 months, compared to controls (p-values < 0.001). Forty percent of patients with GIP(+) C. difficile were (-) by SOC test, suggesting that true CDI was not present. Additional PCR-based testing may not impact outcomes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *POLYMERASE chain reaction
*ENZYME-linked immunosorbent assay
*DIARRHEA
Subjects
Details
- Language :
- English
- ISSN :
- 07328893
- Volume :
- 97
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Diagnostic Microbiology & Infectious Disease
- Publication Type :
- Academic Journal
- Accession number :
- 143233869
- Full Text :
- https://doi.org/10.1016/j.diagmicrobio.2020.115032