C–H Insertion Reactions of Donor/Donor Carbenes: Inception, Investigation, and Insights.

Insertion reactions of donor/donor carbenes have emerged from obscurity to become a versatile method for the synthesis of a variety of cyclic structures with excellent control of diastereo- and enantio-selectivity. This Account describes the origin of this project as part of a natural product synthesis and the ensuing decade of reaction development that has resulted in new asymmetric methods as well as intriguing tangential observations. [ABSTRACT FROM AUTHOR]