Analysis of Genetic Polymorphisms in CCR5, CCR2, Stromal Cell--Derived Factor--1, RANTES, and Dendritic Cell--Specific Intercellular Adhesion Molecule--3--Grabbing Nonintegrin in Seronegative Individuals Repeatedly Exposed to HIV-1.

To determine the influence of host genetics on human immunodeficiency virus (HIV) type I infection, we examined 94 repeatedly exposed seronegative (ES) individuals for polymorphisms in multiple genes and compared the results with those fur 316 HIV-1-seropositive and 425 HIV-1-seronegative individuals. The frequency of homozygous C-C the mokine receptor (CCR) 5-Δ32 was higher in ES (3.2%) than in HIV-1-seropositive individuals (0.0%; P = .012). However, the CCR5-59029A, CCR2-64I, stromal cell-derived factor (SDF)-1-3A, RANTES (regulated on activation, normally T cell-expressed and secreted)-403A, and RANTES-28G polymorphisms were not associated with resistance to HIV-1 in- fection. Furthermore, we identified novel variants in the DC-SIGN (dendritic cell specific intercellular adhesion tool ecule-3-grabbing nonintegrin) repeat region and observed that heterozygous DC-SIGN reduced the risk of HIV-1-seroposfection (3.2% in ES individuals vs. 0.0% in HIV-1-seropositive individuals; P = .011). [ABSTRACT FROM AUTHOR]