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The optimization method for synthesis of technetium-99m-luteolin as radiotracer in the development of cancer drugs from flavonoid.
- Source :
-
Journal of Advanced Pharmaceutical Technology & Research . Apr-Jun2020, Vol. 11 Issue 2, p59-63. 5p. - Publication Year :
- 2020
-
Abstract
- The aim of this study is to find the optimum conditions of labeling luteolin flavonoid compounds with technetium-99m (99mTc) to meet the purity requirements stated in the United States Pharmacopeia. This compound is expected to be a potential radiotracer compound for diagnosing cancer. The optimization method in labeling luteolin with technetium determines the parameters such as pH, SnCl2.2H2O, genistein concentration, and incubation time. Optimization results of Technetium-99m-luteolin labeling obtained optimum pH conditions 8, the amount of SnCl2.2H2O as a reducing agent 60 μL, the optimum amount of luteolin 6 mg/ml, and the optimum incubation time is 30 min. This optimum condition obtained a99mTc-Luteolin radiochemical purity yield of 94.15%. The radiochemical purity percentage of the99mTc-Luteolin compound has fulfilled the requirements listed at United States Pharmacopeia, which is ≥90%. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22314040
- Volume :
- 11
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Advanced Pharmaceutical Technology & Research
- Publication Type :
- Academic Journal
- Accession number :
- 143097946
- Full Text :
- https://doi.org/10.4103/japtr.JAPTR_161_19