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Bioactive Indole Diterpenoids and Polyketides from the Marine-Derived Fungus Penicillium javanicum.
- Source :
-
Chemistry of Natural Compounds . Mar2020, Vol. 56 Issue 2, p379-382. 4p. - Publication Year :
- 2020
-
Abstract
- Recently, a mangrove rhizosphere soil-derived fungus strain I Penicillium javanicum i HK1-23 was selected to be chemically investigated because its extracts showed antibacterial activity and had an interesting HPLC-UV profile. Indole diterpenes are a class of fungal natural products possessing an indole nucleus connected to a cyclized diterpene unit, produced by a variety of fungi including I Aspergillus i , I Penicillium i , and I Dichotomomyces i [[12]]. The results (Table 1) demonstrate that most of the isolated indole diterpenes show weak or no activity against these pathogenic bacteria except for emindole SB ( B 4 b ), which displayed selectivity toward I S. aureus i ATCC 33591 (MIC = 6.25 g/mL). The results (Table 2) reveal that the indole diterpene emindole SB ( B 4 b ) exhibits antifungal activities against four tested crop pathogens, especially strong activity against I G. graminis i , while polyketide penialidin A ( B 9 b ) only showed weak antifungal activities against I G. graminis i and I A. alternata i . [Extracted from the article]
- Subjects :
- *POLYKETIDES
*INDOLE
*DITERPENES
*PENICILLIUM
*NORMAL-phase chromatography
*FUNGI
Subjects
Details
- Language :
- English
- ISSN :
- 00093130
- Volume :
- 56
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Chemistry of Natural Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 143039286
- Full Text :
- https://doi.org/10.1007/s10600-020-03039-6