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Beyond Help: Direct Effector Functions of Human Immunodeficiency Virus Type 1-Specific CD4+ T Cells.
- Source :
-
Journal of Virology . Aug2004, Vol. 78 Issue 16, p8844-8851. 8p. 2 Charts, 13 Graphs. - Publication Year :
- 2004
-
Abstract
- The immune correlates of protection in human immunodeficiency virus type 1 (HIV-1) infection remain poorly defined, particularly the contribution of CD4+ T cells. Here we explore the effector functions of HIV-1-specific CD4 T cells. We demonstrate HIV-1 p24-specific CD4 -T-cell cytolytic activity in peripheral blood mononuclear cells directly ex vivo and after enrichment by antigen-specific stimulation. We further show that in a rare long-term nonprogressor, both an HIV-1-specific CD4+ T-cell clone and CD4+ T cells directly ex vivo exert potent suppression of HIV-1 replication. Suppression of viral replication was dependent on cell-cell contact between the effector CD4+ T cells and the target cells. While the antiviral effector activity of CD8+ T cells has been well documented, these results strongly suggest that HIV-1-specific CD4+ T cells are capable of directly contributing to antiviral immunity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HIV
*CD4 antigen
*T cells
*VIRAL replication
*ANTIVIRAL agents
*ANTIGENS
Subjects
Details
- Language :
- English
- ISSN :
- 0022538X
- Volume :
- 78
- Issue :
- 16
- Database :
- Academic Search Index
- Journal :
- Journal of Virology
- Publication Type :
- Academic Journal
- Accession number :
- 14303120
- Full Text :
- https://doi.org/10.1128/JVI.78.16.8844-8851.2004