Hipertiroidi Hastalarında Tedavi Öncesi ve Sonrası Trombosit/Lenfosit ve Nötrofil/Lenfosit Oranlarının Değerlendirilmesi.

Background: Hyperthyroidism is defined as subnormal (usually undetectable) serum thyrotropin (TSH) with elevated serum levels of free triiodothyronine (free T3) and / or free thyroxine (free T4). Endogenous hyperthyroidism is most commonly due to Graves' disease (GD) or nodular thyroid disease. GD is an autoimmune disease that involves mostly the thyroid gland, the eyes and rarely the skin. The disease is generally recognized by symptoms related to hyperthyroidism. Anti-thyroid medications are used in its treatment, and these medications have anti-inflammatory features besides thyroid hormone synthesis. Thrombocyte/lymphocyte (TLR) and neutrophil/lymphocyte (NLR) rates are systemic inflammatory markers that are obtained from routine blood count, inexpensive and repeatable. It is aimed to evaluate the rates of TLR and NLR before and after treatment in hyperthyroidism. Materials and Methods: The retrospective records of the patients who were admitted to Harran University Medical Faculty Endocrinology Polyclinic were examined, and patients who were diagnosed with hyperthyroidism and started medical treatment were included in the study. Patients with active infection and hemorrhagic pathology were excluded from the study. Laboratory results of the patients at the time of diagnosis and results after 3-6 months were evaluated. It was planned to compare NLR and TLR values before and after medical treatment. Results: In the GD group, there was an increase in TSH, fT3, fT4 leukocyte, neutrophil, lymphocyte and hemoglobin levels before and after treatment, and this increase was statistically significant. Nevertheless, there was a significant increase in TSH, fT3, fT4 values in the toxic nodular goiter (TNG)/ multinodular goiter (MNG) group, while there was no significant difference in leukocyte, neutrophil, lymphocyte and hemoglobin levels before and after treatment. In the GD group, NLR of after treatment was significantly higher than before, but no significant difference was observed in the TLR. Conclusions: GD, which is the most common cause of hyperthyroidism, can change hematological parameters with various mechanisms. Antithyroid medications cause changes in blood count along with thyroid hormone levels. [ABSTRACT FROM AUTHOR]