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Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer.
- Source :
-
International Journal of Molecular Sciences . 4/15/2020, Vol. 21 Issue 8, p2766-2766. 1p. 2 Charts, 4 Graphs. - Publication Year :
- 2020
-
Abstract
- In this work, we sought to investigate the effects of a thiosulfinate-enriched garlic extract, co-administered with 5-fluorouracil (5-FU) or oxaliplatin chemotherapy, on the viability of colon cancer cells (Caco-2 and HT-29). We also addressed the economic feasibility of a new combined treatment of this thiosulfinate-enriched garlic extract, with oxaliplatin that could reduce the dosage and costs of a monotherapy. The thiosulfinate-enriched garlic extract not only enhanced the impact of 5-FU and oxaliplatin (500 µM) in decreasing Caco-2 and HT-29 viability, but also showed a higher effect than standard 5-FU and oxaliplatin chemotherapy as anti-cancer agents. These results provided evidences for the combination of lyophilized garlic extract and 5-FU or oxaliplatin as a novel chemotherapy regimen in colon cancer cells that may also reduce the clinical therapy costs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANCER chemotherapy
*GARLIC
*COLON cancer
*COMBINATION drug therapy
*EXTRACTS
Subjects
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 21
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 142950764
- Full Text :
- https://doi.org/10.3390/ijms21082766