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Cost Effective Use of a Thiosulfinate-Enriched Allium sativum Extract in Combination with Chemotherapy in Colon Cancer.

Authors :
Perez-Ortiz, Jose Manuel
Galan-Moya, Eva Maria
de la Cruz-Morcillo, Miguel Angel
Rodriguez, Juan Francisco
Gracia, Ignacio
Garcia, Maria Teresa
Redondo-Calvo, Francisco Javier
Source :
International Journal of Molecular Sciences. 4/15/2020, Vol. 21 Issue 8, p2766-2766. 1p. 2 Charts, 4 Graphs.
Publication Year :
2020

Abstract

In this work, we sought to investigate the effects of a thiosulfinate-enriched garlic extract, co-administered with 5-fluorouracil (5-FU) or oxaliplatin chemotherapy, on the viability of colon cancer cells (Caco-2 and HT-29). We also addressed the economic feasibility of a new combined treatment of this thiosulfinate-enriched garlic extract, with oxaliplatin that could reduce the dosage and costs of a monotherapy. The thiosulfinate-enriched garlic extract not only enhanced the impact of 5-FU and oxaliplatin (500 µM) in decreasing Caco-2 and HT-29 viability, but also showed a higher effect than standard 5-FU and oxaliplatin chemotherapy as anti-cancer agents. These results provided evidences for the combination of lyophilized garlic extract and 5-FU or oxaliplatin as a novel chemotherapy regimen in colon cancer cells that may also reduce the clinical therapy costs. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16616596
Volume :
21
Issue :
8
Database :
Academic Search Index
Journal :
International Journal of Molecular Sciences
Publication Type :
Academic Journal
Accession number :
142950764
Full Text :
https://doi.org/10.3390/ijms21082766