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Loss of G-protein-signaling modulator 2 accelerates proliferation of lung adenocarcinoma via EGFR signaling pathway.
- Source :
-
International Journal of Biochemistry & Cell Biology . May2020, Vol. 122, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- G-protein-signaling modulator 2 (GPSM2) belongs to a protein family that regulates activation of G proteins and plays an important role in mitotic spindle orientation. However, the role of GPSM2 in lung adenocarcinoma (LUAD) is still unclear. In this study, it was found that GPSM2 correlates with clinicopathological features and patient's prognosis in LUAD. Knocking down GPSM2 promoted LUAD cell proliferation in vitro and in vivo. Mechanistically, it was demonstrated that GPSM2 knockdown accelerates cell proliferation via the EGFR pathway. These results confirmed that GPSM2 played an important role in LUAD. Moreover, GPSM2, as an independent prognostic factor, may serve as a potential drug target and prognostic biomarker in LUAD. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SPINDLE apparatus
*ADENOCARCINOMA
*G proteins
*LUNGS
*CELL proliferation
Subjects
Details
- Language :
- English
- ISSN :
- 13572725
- Volume :
- 122
- Database :
- Academic Search Index
- Journal :
- International Journal of Biochemistry & Cell Biology
- Publication Type :
- Academic Journal
- Accession number :
- 142870090
- Full Text :
- https://doi.org/10.1016/j.biocel.2020.105716