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Rhodium(III)‐Catalyzed Asymmetric Access to Spirocycles through C−H Activation and Axial‐to‐Central Chirality Transfer.
- Source :
-
Angewandte Chemie . 4/27/2020, Vol. 132 Issue 18, p7255-7259. 5p. - Publication Year :
- 2020
-
Abstract
- Axial‐to‐central chirality transfer is an important strategy to construct chiral centers, where the axially chiral reagents are mostly limited to atropomerically stable ones. Reported herein is a RhIII‐catalyzed enantioselective spiroannulative synthesis of nitrones. The coupling proceeds via C−H arylation to give an atropomerically metastable biaryl, followed by intramolecular dearomative trapping under oxidative conditions with high degree of chirality transfer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHIRALITY
*RHODIUM
*CHIRAL centers
*CLASS B metals
*ARYLATION
Subjects
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 132
- Issue :
- 18
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 142811982
- Full Text :
- https://doi.org/10.1002/ange.202000174