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Comparison of FIB-4 Index and Child-Pugh Score in Predicting the Outcome of Hepatic Resection for Hepatocellular Carcinoma.
- Source :
-
Journal of Gastrointestinal Surgery . Apr2020, Vol. 24 Issue 4, p823-831. 9p. - Publication Year :
- 2020
-
Abstract
- <bold>Background and Aims: </bold>The Child-Pugh (CP) score is a widely used method to assess liver function and predict postoperative outcomes in patients with hepatocellular carcinoma (HCC). Recently, the fibrosis index (FIB-4) has been demonstrated to be closely associated with liver fibrosis and cirrhosis. This study aimed to compare the capability of FIB-4 index with CP score in predicting the outcomes for HCC patients after hepatectomy.<bold>Methods: </bold>A total of 495 HCC patients who underwent hepatectomy were enrolled. The performance of the FIB-4 index in predicting postoperative liver failure (PHLF) and overall survival was compared with that of the CP score.<bold>Results: </bold>Of them, 9.3% (46/495) patients developed PHLF. The area under the receiver operating characteristic (ROC) curve of the FIB-4 index for predicting PHLF was greater than that of the CP score (0.744 versus 0.621; P = 0.044). The optimal cutoff value of the FIB-4 index for predicting PHLF was 4.16. Multivariable analyses revealed that the FIB-4 index was an independent predictor of PHLF regardless of the hepatectomy subgroups, but the CP grade was only a significant predictor of PHLF in the minor hepatectomy subgroup. The FIB-4 index (4.16) stratified patients into two distinct overall survival cohorts (P = 0.006). The FIB-4 index also classified patients with the Barcelona Clinical Liver Cancer (BCLC) stages 0 and A into two distinct overall survival cohorts (P = 0.001 and P = 0.034, respectively).<bold>Conclusion: </bold>The FIB-4 index may be a better predictor of PHLF and overall survival in HCC patients with hepatectomy than CP score. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEPATOCELLULAR carcinoma
*RECEIVER operating characteristic curves
*CIRRHOSIS of the liver
*LIVER cancer
*LIVER failure
*RESEARCH
*LIVER tumors
*RESEARCH methodology
*PROGNOSIS
*RETROSPECTIVE studies
*MEDICAL cooperation
*EVALUATION research
*COMPARATIVE studies
*RESEARCH funding
*HEPATECTOMY
Subjects
Details
- Language :
- English
- ISSN :
- 1091255X
- Volume :
- 24
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Journal of Gastrointestinal Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 142764355
- Full Text :
- https://doi.org/10.1007/s11605-019-04123-1