A Method to Enhance Solubility and Tableting Properties by Particle Size Enlargement-Crystallo-Co-Agglomeration.

Crystallo-co-agglomeration is a novel particle design technique, to overcome the limitations of spherical crystallization. The process of Crystallo-co-agglomeration involves crystallization followed by simultaneous agglomeration of the drug with the aid of either a good solvent or a bridging liquid and a bad solvent. The agglomeration is performed using bridging liquid. In the field of powder technology various attempts has been made to design primary and secondary particles of pharmaceutical substances for various applications, such as improvement in solubility of drugs, obtaining suitable polymorph, improvement in micromeritics and compression properties, and modification of bioavailability. [ABSTRACT FROM AUTHOR]