One‐pot synthesis of novel polysubstituted furopyran derivatives via pseudo seven‐component reaction (6 + 1) of isocyanides with bisarylidene Meldrum's acid containing ether groups.

In the present study, a group of polysubstituted furopyran derivatives possessing ether spacer groups were synthesized under good‐to‐exceptional yields via cycloaddition of bisarylidene Meldrum's acid derivatives (1 mmol) with isocyanides (6 mmol) within dichloromethane (CH2Cl2) for 3 to6 hours at room temperature with no assistance from any type of catalysts. The structure of the products was then confirmed by Fourier Transform‐infrared spectroscopy, 1H‐nuclear magnetic resonance spectroscopy, 13C‐nuclear magnetic resonance spectroscopy, and elemental analysis. Moreover, the 5c, 5d, and 5f compounds exhibited favorable pharmaceutical behavior as antibacterial. [ABSTRACT FROM AUTHOR]