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α,α‐Dibromoketone precursors in the synthesis of some new thiazole derivatives: Thiazol‐2‐yl hydrazonobutanoates, thiazol‐2‐yl pyrazole‐4‐carboxylates and acids.
- Source :
-
Journal of Heterocyclic Chemistry . May2020, Vol. 57 Issue 5, p2173-2183. 11p. - Publication Year :
- 2020
-
Abstract
- In the present study, α,α‐dibromoacetophenones are used as efficient precursors for the facile synthesis of several new hydrazonothiazoles, ethyl 3‐((4‐arylthiazol‐2‐yl)hydrazono)butanoates, which undergo Vilsmeier‐Haack cyclization to obtain thiazolylpyrazole esters, ethyl 3‐methyl‐1‐(4‐arylthiazol‐2‐yl)‐1H‐pyrazole‐4‐carbxylates, basic hydrolysis of which gives the corresponding acids, 3‐methyl‐1‐(4‐arylthiazol‐2‐yl)‐1H‐pyrazole‐4‐carbxylic acids. All these compounds are tested for antibacterial activity against Gram‐positive bacteria Staphylococcus aureus and Bacillus subtilis; Gram‐negative bacteria Escherichia coli and Pseudomonas aeruginosa and antifungal activity against Saccharomyces cerevisiae and Candida albicans. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0022152X
- Volume :
- 57
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Heterocyclic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 142723961
- Full Text :
- https://doi.org/10.1002/jhet.3937