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Insights into CD8 T Cell Activation and Exhaustion from a Mouse Gammaherpesvirus Model.

Authors :
Sarawar, Sally R.
Shen, Jadon
Dias, Peter
Source :
Viral Immunology. Apr2020, Vol. 33 Issue 3, p215-224. 10p.
Publication Year :
2020

Abstract

(S.R.S.) I was introduced to viral immunology while working in Peter Doherty's laboratory in the early stages of my research career, inspiring a lifelong interest in this area. During those early years under Peter's mentorship, we studied a mouse gammaherpesvirus model (murine gammaherpesvirus-68 [MHV-68]) that provided a useful small animal model for investigating the immunological control of gammaherpesvirus infection. Interestingly, while CD4 T cells were not required for acute control of MHV-68 in the lung, CD8 T cell-mediated control was progressively lost in the absence of CD4 T cell help, leading to viral recrudescence. This was one of several early studies showing that CD8 T cell control of persistent viral infections was lost in the absence of CD4 T cell help, preceding the concept of CD8 T cell exhaustion. Further studies showed that MHV-68 infection of mice offered a unique model for comparing the mechanisms of acute and long-term control of a persistent viral infection and developing strategies for reversing T cell exhaustion. Here, we provide a brief review of the literature on CD8 T cell activation and exhaustion in this model, focusing on the role of CD40 and B7 family members and including some previously unpublished data. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08828245
Volume :
33
Issue :
3
Database :
Academic Search Index
Journal :
Viral Immunology
Publication Type :
Academic Journal
Accession number :
142721295
Full Text :
https://doi.org/10.1089/vim.2019.0183