Helical β-Peptide Inhibitors of the p53-hDM2 Interaction.

This article focuses on a study related to helical β-peptide inhibitors of the p53-hDM2 interaction. β-Peptides differ from α-peptides by one additional backbone carbon atom and by resistance to metabolism and proteolysis.β-Peptides fold into helices, sheets, and turns and have well-recognized potential as peptidomimetics. hDM2 is recognized in vivo by a short α-helix within the activation domain of p53, the transcription factor that controls cell fate in response to stress.