Back to Search
Start Over
Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis.
- Source :
-
FASEB Journal . Feb2004, Vol. 18 Issue 2, p300-310. 11p. 5 Color Photographs, 2 Black and White Photographs, 1 Diagram, 1 Chart, 5 Graphs. - Publication Year :
- 2004
-
Abstract
- Cyclooxygenasel (COX1) and COX2 mediate the rate-limiting step in arachidonic acid metabolism. Expression of COX2 mRNA and protein is often enhanced in various human cell types by inflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor α (TNFα). IL-1β enhanced expression of various prostanoids and this expression was blocked by COX2 selective inhibitors. IL-1β markedly induced angiogenesis in vitro and in vivo, which was significantly inhibited by COX2 selective inhibitors but not by a vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. In contrast, COX2 selective inhibitors only partially blocked VEGF-induced angiogenesis. EP2, EP4 (prostaglandin E2 receptors) agonists and thromboxane A2 (TXA2) receptor agonists induced angiogenesis in vitro and in vivo; IL-1β-induced angiogenesis was blocked by an EP4 antagonist and a TXA2 receptor antagonist. IL-1β induced much less angiogenesis in cornea of COX2 knockout mice than that of wild-type mice. This is the first report that COX2 and some prostanoids play a key role in IL-1β-induced angiogenesis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 08926638
- Volume :
- 18
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- FASEB Journal
- Publication Type :
- Academic Journal
- Accession number :
- 14252173
- Full Text :
- https://doi.org/10.1096/fj.03-0473com