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Qualitative analysis of contribution of intracellular skeletal changes to cellular elasticity.

Authors :
Kwon, Sangwoo
Kim, Kyung Sook
Source :
Cellular & Molecular Life Sciences. Apr2020, Vol. 77 Issue 7, p1345-1355. 11p. 1 Color Photograph, 1 Diagram, 2 Charts.
Publication Year :
2020

Abstract

Cells are dynamic structures that continually generate and sustain mechanical forces within their environments. Cells respond to mechanical forces by changing their shape, moving, and differentiating. These reactions are caused by intracellular skeletal changes, which induce changes in cellular mechanical properties such as stiffness, elasticity, viscoelasticity, and adhesiveness. Interdisciplinary research combining molecular biology with physics and mechanical engineering has been conducted to characterize cellular mechanical properties and understand the fundamental mechanisms of mechanotransduction. In this review, we focus on the role of cytoskeletal proteins in cellular mechanics. The specific role of each cytoskeletal protein, including actin, intermediate filaments, and microtubules, on cellular elasticity is summarized along with the effects of interactions between the fibers. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1420682X
Volume :
77
Issue :
7
Database :
Academic Search Index
Journal :
Cellular & Molecular Life Sciences
Publication Type :
Academic Journal
Accession number :
142511967
Full Text :
https://doi.org/10.1007/s00018-019-03328-6