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Norharman and alcohol-dependency in male Wistar rats
- Source :
-
European Neuropsychopharmacology . Oct2004, Vol. 14 Issue 5, p361-366. 6p. - Publication Year :
- 2004
-
Abstract
- We examined the effects of ethanol ingestion to rats on levels of the β-carboline norharman in plasma, brain and liver at the end of ethanol ingestion and 10 h after withdrawal. We also investigated the effect of exogenously administered norharman on the behavioural signs of alcohol withdrawal. Ethanol was given by a liquid diet for 21 days. Norharman plasma levels in alcohol fed rats were significantly elevated compared to both control rats and to rats 10 h after withdrawal. Norharman levels in brains and livers showed a similar pattern. The capacity of the livers of both alcohol-dependent and withdrawal rats to catabolise norharman was significantly reduced compared to control rats. Norharman injected intraperitoneally (6.3 mg/kg) attenuated the behavioural signs of alcohol withdrawal significantly. The mechanism behind the increased norharman levels in alcohol-dependent rats may be inhibition of the synthesis and/or activity of liver enzyme(s) responsible for the breakdown of norharman. [Copyright &y& Elsevier]
- Subjects :
- *ALCOHOLIC beverages
*DRINKING behavior
*ALCOHOL
*DIET
Subjects
Details
- Language :
- English
- ISSN :
- 0924977X
- Volume :
- 14
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- European Neuropsychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 14249950
- Full Text :
- https://doi.org/10.1016/j.euroneuro.2003.10.007