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Alternatively Constructed Estrogen Receptor Alpha-Driven Super-Enhancers Result in Similar Gene Expression in Breast and Endometrial Cell Lines.
- Source :
-
International Journal of Molecular Sciences . Mar2020, Vol. 21 Issue 5, p1630. 1p. 6 Graphs. - Publication Year :
- 2020
-
Abstract
- Super-enhancers (SEs) are clusters of highly active enhancers, regulating cell type-specific and disease-related genes, including oncogenes. The individual regulatory regions within SEs might be simultaneously bound by different transcription factors (TFs) and co-regulators, which together establish a chromatin environment conducting to effective transcription. While cells with distinct TF profiles can have different functions, how different cells control overlapping genetic programs remains a question. In this paper, we show that the construction of estrogen receptor alpha-driven SEs is tissue-specific, both collaborating TFs and the active SE components greatly differ between human breast cancer-derived MCF-7 and endometrial cancer-derived Ishikawa cells; nonetheless, SEs common to both cell lines have similar transcriptional outputs. These results delineate that despite the existence of a combinatorial code allowing alternative SE construction, a single master regulator might be able to determine the overall activity of SEs. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ESTROGEN receptors
*CELL lines
*GENE expression
*TRANSCRIPTION factors
*BREAST
Subjects
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 21
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 142478152
- Full Text :
- https://doi.org/10.3390/ijms21051630