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Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna.
- Source :
-
Scientific Reports . 3/27/2020, Vol. 10 Issue 1, p1-15. 15p. - Publication Year :
- 2020
-
Abstract
- Lipids play a significant role in regulation of health and disease. To enhance our understanding of the role of lipids in regulation of lifespan and healthspan additional studies are required. Here, UHPLC-MS/MS lipidomics was used to measure dynamic changes in lipid composition as a function of age and gender in genetically identical male and female Daphnia magna with different average lifespans. We demonstrate statistically significant age-related changes in triglycerides (TG), diglycerides (DG), phosphatidylcholine, phosphatidylethanolamine, ceramide and sphingomyelin lipid groups, for example, in males, 17.04% of TG lipid species decline with age whilst 37.86% increase in relative intensity with age. In females, 23.16% decrease and 25.31% increase in relative intensity with age. Most interestingly, the rate and direction of change can differ between genetically identical female and male Daphnia magna, which could be the cause and/or the consequence of the different average lifespans between the two genetically identical genders. This study provides a benchmark dataset to understand how lipids alter as a function of age in genetically identical female and male species with different average lifespan and ageing rate. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LIPIDS
*DAPHNIA magna
*TRIGLYCERIDES
*DIGLYCERIDES
*CERAMIDES
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Scientific Reports
- Publication Type :
- Academic Journal
- Accession number :
- 142435747
- Full Text :
- https://doi.org/10.1038/s41598-020-62476-z