NICE comes of age.

In April 1999, the British government established a new institute, NICE, to assess the clinical and cost‐effectiveness of medicines and devices for use by the National Health Service in England. To mark its 21st birthday, NICE's former chair, Michael D. Rawlins, and former chief executive, Andrew Dillon, reflect on the organisation's contributions – plus a few controversies along the way In April 1999, the British government established a new institute, NICE, to assess the clinical and cost‐effectiveness of medicines and devices for use by the National Health Service in England. To mark its 21st birthday, NICE's former chair, Michael D. Rawlins, and former chief executive, Andrew Dillon, reflect on the organisation's contributions – plus a few controversies along the way. [ABSTRACT FROM AUTHOR]