Total synthesis of carbazole alkaloid clausamine E.

In this study, the total syntheses of 1,3,4-trisubstituted carbazole alkaloid clausamine E was accomplished via an eight-step sequence using construction of the 1,4-dioxygenated carbazole framework based on the cyclocarbonylation between 3-iodo-2-(prop-2-enyl)indole and CO (1 atm) in the presence of tributyl(vinyl)tin and a Pd catalyst. Image 1 • The total synthesis of clausamine E has been accomplished via an eight-step sequence. • Synthesis of 1,4-dioxygenated carbazoles by Pd-catalyzed cyclocarbonylation. • This method could be used as a versatile method to synthesize substituted carbazoles. [ABSTRACT FROM AUTHOR]