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Diagnostic and prognostic values of anti glucose-6-phosphate isomerase antibodies in community-recruited patients with very early arthritis.
- Source :
-
Clinical & Experimental Immunology . Sep2004, Vol. 137 Issue 3, p606-611. 6p. - Publication Year :
- 2004
-
Abstract
- The objective of this study was to determine the diagnostic and prognostic values of antiglucose-6-phosphate isomerase (GPI) antibodies in patients with very early arthritis. Anti-GPI antibodies were measured by ELISA using purified GPI from rabbit muscle in: (i) 383 sera from healthy blood donors ( n = 120), well-established rheumatoid arthritis (RA) ( n = 99) and non-RA differentiated arthritis (NRADA) ( n = 164) patients; (ii) 195 sera obtained from community-recruited patients with very early inflammatory arthritis (VErA cohort) that were studied for 1 year and classified as having RA ( n = 116), NRADA ( n = 41), and undifferentiated arthritis (UA) ( n = 38) after the follow-up period. The criterion for severity was the progression of radiographic damage. Prevalence of anti-GPI antibodies was significantly higher in well-established RA patients (45·4%) compared to healthy subjects (2·5%). Anti-GPI antibodies were also present in sera from NRADA: systemic lupus erythematosus 53%, polymyositis 45·4%, adult-onset Still's disease 44%, systemic sclerosis 42·8%, spondylarthropathies 25% and primary Sjögren ’s syndrome 5·8%. No significant association was found between the presence of anti-GPI antibodies and the 3 diagnostic groups from the VErA cohort. No correlation was observed between anti-GPI and autoantibodies usually associated with RA. Anti-GPI antibodies were not predictive of radiological progression in patients with very early arthritis. Thus, anti-GPI antibodies are not useful for discriminating RA from non-RA rheumatic diseases and do not constitute a predictive factor of structural damage. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ARTHRITIS
*IMMUNOGLOBULINS
*ISOMERASES
*GLUCOSE
*RHEUMATOID arthritis
*GLOBULINS
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 137
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14228234
- Full Text :
- https://doi.org/10.1111/j.1365-2249.2004.02552.x