Back to Search
Start Over
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
- Source :
-
Lipids in Health & Disease . 3/13/2020, Vol. 19 Issue 1, p1-10. 10p. 1 Color Photograph, 4 Graphs. - Publication Year :
- 2020
-
Abstract
- Background: Obesity is a metabolic imbalance characterized by excessive deposition of white fat. The browning of white fat can effectively treat obesity and related diseases. Although Dlgap1 (Discs, Large (Drosophila) Homolog-Associated Protein 1) is suspected to have an effect on this process, no empirical evidence is available. Methods: To understand the role of Dlgap1, we cultured white and brown fat cells, then performed overexpression and knockout experiments. Results: We found that Dlgap1 overexpression in brown adipocytes inhibits brown-fat-related gene expression, promotes white-fat-related genes, while also increasing brown-adipocyte proliferation and apoptosis. However, the gene overexpression has no effect on brown adipocyte maturation. Knocking out Dlgap1 in white fat cells promotes the expression and inhibition of brown-fat-related and white-fat-related genes, respectively. Additionally, the knockout inhibits white fat cell proliferation and apoptosis, while also promoting their maturation. Conclusions: Dlgap1 negatively regulates the browning of white adipocytes by influencing cell proliferation and apoptosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1476511X
- Volume :
- 19
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Lipids in Health & Disease
- Publication Type :
- Academic Journal
- Accession number :
- 142224347
- Full Text :
- https://doi.org/10.1186/s12944-020-01230-w