载绞股蓝皂苷纳米结构脂质载体的制备及体外评价.

Objective ：To prepare gype no sides--loaded nanostructured lipid carriers (GPS-NLCs) by hot melting high-pressure homogenization method and investigate its properties and in vitro release. Methods: The effects of stirring power, stirring time, homogeneous pressure and cycle times on the particle size and polydispersity index (PDI) of GPS-NLCs were investigated by single-factor test. The morphology of GPS-NLCs was characterized by transmission electron microscopy (TEM) and dissolution behavior of GPS-NLCs was evaluated in vitro. Results: The optimized particle size of GPS-NLCs was (159 .6士6 .6) nm, PDI was (0 .221 士CX 009) and entrapment efficiency (EE) and drug loading (DL) were (74，30士3 .17)5 and (4 .91 士0 .39)， respectively. As compared with GPS powder and gypenosides-loaded solid lipid nano particles, GPS-NLCs could improve drug dissolution significantly. Conclusion: The particle size distribution of GPS-NLCs prepared by high pressure homogenization method was uniform，the drug entrapment efficiency was high，the dissolution rate of the drug in vitro could be significantly improved with obvious sustained drug release. [ABSTRACT FROM AUTHOR]