Synthesis of Novel 3-Methoxy-4-Phenyl-1-p-Tolyl-1H-Pyrrole-2,5-Dione Derivatives and Study of Their Antimicrobial Activity.

A series of 3-methoxy-4-phenyl-1-p-tolyl-1H-pyrrole-2,5-dione 5a-l were synthesized with almost 80 to 90% yield. All the maleimides were well characterised and screened against panel of four fungal strains and two bacterial strains. The structures of compounds were characterized by their IR, NMR, mass and elemental analysis. The minimum inhibitory concentrations (MICs) of synthesized maleimides were carried out by broth microdilution method. Out of tested maleimides, compounds 5f and 5j registered significant activity antibacterial activity. While rest of compounds showed moderate to marginal antimicrobial activity. [ABSTRACT FROM AUTHOR]