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Asymmetric Total Synthesis of the Complex Polycyclic Xanthone FD‐594.
- Source :
-
Angewandte Chemie . 3/9/2020, Vol. 132 Issue 11, p4390-4394. 5p. - Publication Year :
- 2020
-
Abstract
- A highly convergent approach was developed to achieve the first asymmetric and scalable total synthesis of FD‐594, a complex polycyclic xanthone natural product from Streptomyces sp. TA‐0256, in a longest linear sequence (LLS) of 20 steps. The trans‐9,10‐dihydrophenanthrene‐9,10‐diol fragment (B‐C‐D ring) was generated through a new strategy involving asymmetric dihydroxylation followed by Cu‐mediated oxidative cyclization. Late‐stage stereoselective glycosylation assembled the angular hexacyclic framework with a β‐linked 2,6‐dideoxy trisaccharide fragment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00448249
- Volume :
- 132
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie
- Publication Type :
- Academic Journal
- Accession number :
- 141999163
- Full Text :
- https://doi.org/10.1002/ange.201915787