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Relationship between autoantibodies to erythropoietin receptor and renal outcome in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis.
- Source :
-
Biomarkers . Mar2020, Vol. 25 Issue 2, p194-200. 7p. - Publication Year :
- 2020
-
Abstract
- Purpose: We examined the relationship between autoantibodies to erythropoietin receptor (EPOR) and renal outcome in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Materials and methods: Sixty-three Japanese patients with AAV were enrolled and followed for a median of 31.4 months. Patients were screened for serum anti-EPOR antibodies using an enzyme-linked immunosorbent assay. Associations of anti-EPOR antibodies with clinical parameters were analyzed using logistic-regression models. Results: Anti-EPOR antibodies were detected in 7 (11%) of the 63 patients, and levels of the antibodies decreased with immunosuppressive therapy. The presence of anti-EPOR antibodies was associated with a higher Birmingham vasculitis activity score. In addition, anti-EPOR antibodies were more frequently observed in patients with renal outcomes, which was defined as a sustained 50% reduction in the estimated glomerular filtration rate from baseline, than in those without. Multiple logistic regression analysis revealed that presence of anti-EPOR antibodies, as well as age at disease onset, were as risk factors for the renal outcome. Conclusion: Anti-EPOR antibodies were associated with the progression of renal dysfunction in patients with AAV. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1354750X
- Volume :
- 25
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 141957079
- Full Text :
- https://doi.org/10.1080/1354750X.2020.1727014