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Association of Urine Haptoglobin With Risk of All-Cause and Cause-Specific Mortality in Individuals With Type 2 Diabetes: A Transethnic Collaborative Work.
- Source :
-
Diabetes Care . Mar2020, Vol. 43 Issue 3, p625-633. 9p. - Publication Year :
- 2020
-
Abstract
- <bold>Objective: </bold>Haptoglobin is an acute-phase reactant with pleiotropic functions. We aimed to study whether urine haptoglobin may predict risk of mortality in people with type 2 diabetes.<bold>Research Design and Methods: </bold>We employed a transethnic approach with a cohort of Asian origin (Singapore) (N = 2,061) and a cohort of European origin (France) (N = 1,438) included in the study. We used survival analyses to study the association of urine haptoglobin with risk of all-cause and cause-specific mortality.<bold>Results: </bold>A total of 365 and 525 deaths were registered in the Singapore cohort (median follow-up 7.5 years [interquartile range 3.5-12.8]) and French SURDIAGENE cohort (median follow-up 6.8 years [interquartile range 4.3-10.5], respectively. Singapore participants with urine haptoglobin in quartiles 2 to 4 had higher risk for all-cause mortality compared with quartile 1 (unadjusted hazard ratio [HR] 1.47 [95% CI 1.02-2.11], 2.28 [1.62-3.21], and 4.64 [3.39-6.35], respectively). The association remained significant in quartile 4 after multiple adjustments (1.68 [1.15-2.45]). Similarly, participants in the French cohort with haptoglobin in quartile 4 had significantly higher hazards for all-cause mortality compared with quartile 1 (unadjusted HR 2.67 [2.09-3.42] and adjusted HR 1.49 [1.14-1.96]). In both cohorts, participants in quartile 4 had a higher risk of mortality attributable to cardiovascular disease and infection but not malignant tumor.<bold>Conclusions: </bold>Urine haptoglobin predicts risk of mortality independent of traditional risk factors, suggesting that it may potentially be a novel biomarker for risk of mortality in patients with type 2 diabetes. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TYPE 2 diabetes
*URINE
*MORTALITY
*BIOMARKERS
*CAUSES of death
*RESEARCH
*BLOOD proteins
*RESEARCH methodology
*CARDIOVASCULAR diseases
*PROGNOSIS
*EVALUATION research
*MEDICAL cooperation
*ETHNOLOGY research
*COMPARATIVE studies
*SURVIVAL analysis (Biometry)
*GLOBULINS
*LONGITUDINAL method
*DIABETIC angiopathies
*DISEASE complications
CARDIOVASCULAR disease related mortality
Subjects
Details
- Language :
- English
- ISSN :
- 01495992
- Volume :
- 43
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Diabetes Care
- Publication Type :
- Academic Journal
- Accession number :
- 141908633
- Full Text :
- https://doi.org/10.2337/dc19-1295