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Immunokinetics of autoreactive CD4 T cells in blood: a reporter for the “hit-and-run” autoimmune attack on pancreas and diabetes progression
- Source :
-
Journal of Autoimmunity . Sep2004, Vol. 23 Issue 2, p151-160. 10p. - Publication Year :
- 2004
-
Abstract
- Little is known about the fate of autoreactive CD4 T cells in blood. Using a mouse model for spontaneous autoimmune diabetes we demonstrated that the status of the autoimmune process in pancreas could be pictured through the frequency and phenotype of autoreactive CD4 T cells in the blood. Early during the prediabetic stage, the frequency of these cells in blood decreased as a consequence of their recruitment in the pancreas. This was followed by an imbalance between CD4+CD25+ and CD4+CD69+ T cells in the pancreas that was mirrored in the phenotype of autoreactive T cells in the blood. Waves of activated CD4+CD69+ T cells in blood preceded the disease onset suggesting that the autoimmune attack on pancreas is a discontinuous “hit-and-run” rather than a continuous process. Tracking autoreactive CD4 T cells in blood may help in identifying prediabetic humans and monitoring the disease progression during therapeutic interventions. [Copyright &y& Elsevier]
- Subjects :
- *DIABETES
*T cells
*BLOOD
*HOMEOSTASIS
Subjects
Details
- Language :
- English
- ISSN :
- 08968411
- Volume :
- 23
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Autoimmunity
- Publication Type :
- Academic Journal
- Accession number :
- 14189545
- Full Text :
- https://doi.org/10.1016/j.jaut.2004.06.006