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STAT3, tumor microenvironment, and microvessel density in diffuse large B cell lymphomas.
- Source :
-
Leukemia & Lymphoma . Mar2020, Vol. 61 Issue 3, p567-574. 8p. - Publication Year :
- 2020
-
Abstract
- Constitutively activated STAT3 is correlated with more advanced clinical stage and overall poor survival of diffuse large B-cell lymphoma (DLBCL). The aim of this study was to evaluate STAT3 and Ki67 tumor cell expression, inflammatory cell infiltration, microvascular density in DLBCL bioptic specimens. RNA-scope showed that activated B cell (ABC) tissue samples contained a significant higher number of STAT3+ cells as compared to germinal center B (GCB) tissue samples. Immunohistochemical analysis showed a significant increased levels of CD3, CD8, CD68, CD163, CD34, and Ki67 positive cells in ABC patients. A positive correlation between STAT3 and CD3, CD8, CD68, and CD163 was evidenced in ABC group. In ABC group, we found also a positive correlation between CD8 and CD34 and a positive correlation between Ki67 and, CD68, and CD163. These data indicate that in ABC—as compared to GCB-DLBCL, a higher STAT3 expression is associated with a higher CD163+ TAM and CD8+ cell infiltration which induces a strong angiogenic response. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIFFUSE large B-cell lymphomas
*TUMOR microenvironment
*GERMINAL centers
*B cells
Subjects
Details
- Language :
- English
- ISSN :
- 10428194
- Volume :
- 61
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Leukemia & Lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 141842092
- Full Text :
- https://doi.org/10.1080/10428194.2019.1678154